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Full Catalog (page 17)
Product Number Product Name Molecular Formula Cas. No. Description Notes Alt. Name Alt. Name 2
PR 3702 N2-
Dimethylguanosine		 C12H17N5O5  2140-67-2         
PR 3703 Guanosine C10H13N5O5  118-00-3         
PR 3705 8-Oxo-2'-deoxyadenosine C10H13N5O4  62471-63-0 

For the phosphoramidite, see BA 0005.

 

 This is just one example of the "DNA damaged" nucleosides that we offer.   8-Hydroxy-2'-deoxyadenosine   
PR 3710 8-Oxo-2'-deoxyguanosine C10H13N5O5  88847-89-6  Nucleoside of interest due to occurrence as abnormal base residue in cellular DNA. For the phosphoramidite, see BA 0010.

 

 This is just one example of the "DNA damaged" nucleosides that we offer.  8-Hydroxy-2'-deoxyguanosine   
PR 3720 8-Oxo-N2-isobutyryl-2'-
deoxyguanosine		 C14H19N5O6  136859-76-2  For the phosphoramidite, see BA 0010.

 

   8-Hydroxy-N2-isobutyryl-2'-deoxyguanosine   
PR 3725 Inosine C10H12N4O5  58-63-9         
PR 3727 2',3'-Dideoxyinosine C10H12N4O3  69655-05-6         
PR 3730 2',3'-O-Isopropylidene-5'-oxo-
8,5'-cycloadenosine		 C13H13N5O4  33066-26-1         
PR 3732 N6-
Methyladenosine		 C11H15N5O4  1867-73-8     

N-Methyladenosine

 

6-Methylaminopurine-D-riboside

 
PR 3735 Isoguanosine C10H13N5O5  1818-71-9  The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities. We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Isoguanosines are important in the field of non-natural base pairing. In 1989, Benner and co-workers1 reported the enzymatic incorporation of iso-G into RNA and DNA and characterized the distinct non-natural base pairing that resulted, especially pairing involving the similarly transposed isomer of dC known as iso-dC (we offer the closely-related compound 5-Methyliso-dC, PY 7255

Iso-G and Iso-dG are part of a family that includes Guanosine (PR 3703) , 2'-Deoxyguanosine (PR 3452) , the isomeric nucleosides 2'-Deoxypseudoguanosine (Pseudo-dG, PRA 10103) , 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104) and the phosphoramidites Pseudo-dG CEP (BA 0312) and Pseudoiso-dG CEP (BA 0314)

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Switzer, C. Y.; Moroney, S. E.; Benner, S. A. J. Am. Chem. Soc. 1989, 111, 8322-8323.

 

Isoguanosine (Iso-G, PR 3735) and 2'-Deoxyisoguanosine (Iso-dG, PR 3465) are isomeric with G/dG, differing by transposition of the carbonyl group at position 6 of G or dG with the C-NH2 group at position 2, providing a novel hydrogen bond donor/acceptor pattern.

 

 Iso-G;

2-hydroxy adenosine;

1,2-dihydro-2-oxo adenosine 		  
PR 3740 N6-Methyl-2'-
deoxyadenosine		 C11H15N5O3  2002-35-9  Methylation of specific adenines in a DNA strand by dam methylase (EC2.1.1.37) is thought to be involved in DNA strand replication during post-replicative mismatch repair and in central gene expression.       
PR 3745 N2-Isobutyl-2'-
deoxyguanosine		 C14H21N5O4  142554-22-1         
PR 3748 N1-Methyl-2'-
deoxyguanosine		 C11H15N5O4  5132-79-6  When incorporated into nucleic acids, may be of use in studies of enzymatic and chemical methylation as well as Tm-leveling studies. Please contact us if you are interested in the cyanoethyl phosphoramidite of this nucleoside for incorporation into oligonucleotides.
 		   2'-Deoxy-1-methylguanosine  1-Methyl-2'-deoxyguanosine 
PR 3750 N2-Methyl-2'-
deoxyguanosine		 C11H15N5O4  19916-77-9         
PR 3755 O6-Methyl-2'-
deoxyguanosine		 C11H15N5O4  964-21-6         
PR 3757 O6-
Methylguanosine		 C11 H15 N5O5  7803-88-5         
PR 3760 2'-O-Methylguanosine C11H15N5O5  2140-71-8         
PR 3770 2'-O-Methylinosine C11H14N4O5  3881-21-8         
PR 3780 7-Methylinosine C11H14N4O5  20245-33-4  7-Methylinosine is an alternative to MESG for measurement of inorganic phosphate in the presence of purine nucleoside phosphorylase (PNPase).

Rieger, C. E.; Lee, J.; Turnbull, J. L. Anal. Biochem. 1997, 246, 86-95.

 		      
PR 3790 7-Methyl-6-thioguanosine C11H15N5O4S   55727-10-1  7-Methyl-6-thioguanosine (MESG, Abs = 330 nm) forms 7-methyl-6-thioguanine (Abs = 355 nm) in the presense of inorganic phosphate and purine nucleoside phosphorylase (PNP) and thus constitutes a rapid and sensitive assay for phosphate. If inorganic pyrophosphatase is present, MESG may also be used to detect inorganic pyrophosphate.

MESG should be used as soon as possible after dissolution.

1. Webb, M. R. PNAS 1992, 89, 4884-4887.

2. Wedler, F. C.; Ley, B. W.; Moyer, M. L. Anal. Biochem. 1994, 218, 449-453.

3. Cheng, J.; Farutin, V.; Wu, Z.; Jacob-Mosier, G.; Riley, B.; Hakimi, B.; Cordes, E. H. Bioorg. Chem. 1999, 27, 307-325.
 

   MESG   
PR 3795 8-Hydroxyguanosine C10H13N5O6  3868-31-3      8-Oxoguanosine  8-Oxo-G 
PR 3796 8-Bromoguanosine C10H12BrN2O5  4016-63-1    This product has been discontinued.     
PR 3797 8-Benzyloxyguanosine C17H19N5O6  3868-36-8         
PR 3800 5'-Oxo-8,5'-cycloadenosine C10H9N5O4  869355-06-6         
PR 3810 5'-Oxo-2'-deoxy-8,5'-
cycloadenosine		 C10H9N5O3  869355-08-8         
PR 3840 O6-Phenyl-2'-
deoxyinosine		 C16H16N4O4  114485-36-8  Nucleophilic displacement of the O6-phenyl group offers a convenient route to various 6-substituted purine deoxyribosides.