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Full Catalog (page 22)
Product Number Product Name Molecular Formula Cas. No.

PRA 10032

7-(3-Nitrophenyl)-7-deaza-2'-
deoxyadenosine

C17H17N5O5 

None Assigned 

Alternate Name(s):

5-(3-Nitrophenyl)-2'-deoxytubercidin

PRA 10035

7-Deazaadenosine (tubercidin)

C11H14N4O4 

69-33-0 

Description

Further discounts available for larger orders. Pricing shown is for tubercidin obtained from fermentation. We also offer synthetic tubercidin, $325.00 (25 mg); $995.00 (100 mg).

PRA 10036

5-Iodo-2'-deoxytubercidin

C11H13IN4O3 

166247-63-8 

PRA 10040

7-Deaza-2'-deoxyguanosine

C11H14N4O4 

86392-75-8 

PRA 10042

7-Methyl-7-deaza-2'deoxyguanosine

C12H16N4O4 

90358-21-7 

PRA 10045

7-Deazaguanosine

C11H14N4O5 

62160-23-0 

Alternate Name(s):

2-Amino-1,7-dihydro-7-β-ribofuranosyl-4-H-pyrrolo[2,3-d]pyrimidin-4-one

PRA 10047

5-Amino-3-β-D-
ribofuranosylthiazolo[4,5-d]
pyrimidin-2,7(3H,6H)-
dione

C10H12N4O6S 

122970-40-5 

Description

Also known as TOG, 7-thia-8-oxoguanosine, Immunosine, Immusine, Isatoribine. An antiviral and immunostimulatory agent that activates, among other things, Toll-like receptor 7 (TLR7). See: Lee, J.; Chuang, T.-H.; Redecke, V.; She, L.; Pitha, P. M.; Carson, D. A.; Raz, E.; Cottam, H. B., Proc. Natl Acad. Sci. USA 2003, 100, 6646-6651 and references therein. Multigram quantities available. Call for pricing.

Notes

An antiviral and immuno-stimulatory agent.

Alternate Name(s):

TOG

7-Thia-8-oxoguanosine

PRA 10050

7-Deaza-2'-deoxyxanthosine

C11H13N3O5 

96022-82-1 

PRA 10055

5'-O-(Dimethoxytrityl)-7-deaza-2'-
deoxyxanthosine

C32H31N3O7 

869355-16-8 

PRA 10060

1-(β-D-2-Deoxyribofuranosyl)-5-
nitroindole

C13H14N2O5 

191421-10-0 

PRA 10070

1-(β-D-2-Deoxyribofuranosyl)-4-
methylindole

C14H17NO3 

180420-84-2 

Notes

This product has been discontinued.

PRA 10080

1-(5-O-(Dimethoxytrityl)-β-D-2-
deoxyribofuranosyl)-4-methylindole

C35H35NO5 

180737-32-0 

Notes

This product has been discontinued.

PRA 10090

1-(5-O-(Dimethoxytrityl)-β-D-2-
deoxyribofuranosyl)-5-nitroindole

C34H32N2O7 

869355-18-0 

PRA 10095

5-Iodotubercidin

C11H13IN4O4 

24386-93-4 

Description

Competitive inhibitor of MAP kinase ERK2. Also inhibits insulin receptor kinase, adenosine kinase, and various serine and threonine kinases. Soluble in DMSO.

Alternate Name(s):

7-Deaza-7-iodoadenosine

ITU

PRA 10100

5'-O-(Dimethoxytrityl)-N2-
(dimethylaminomethylidene)-7-deaza-
2'-deoxyguanosine

C35H37N5O6 

111869-42-2 

PRA 10103

2'-Deoxypseudoguanosine

C10H13N5O4 

912814-74-5 

Description

The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities.  We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Pseudo-dG (PRA 10103) is a guanosine isomer that was recently reported by Hosmane and co-workers.1  We also offer Pseudo-dG CEP (BA 0312) , which may be used to incorporate Pseudo-dG nucleotides into DNA.

Pseudo-dG and Pseudo-dG CEP are part of a family that includes Guanosine (PR 3703) , 2'-Deoxyguanosine (PR 3452) , the isomeric nucleosides Isoguanosine (Iso-G, PR 3735) , 2'-Deoxyisoguanosine (Iso-dG, PR 3465) , 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104) , and the phosphoramidite Pseudoiso-dG CEP (BA 0314).

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367.  See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51, 694-698.

Notes

2'-Deoxypseudoguanosine (Pseudo-dG) is related to dG by transposition of the nitrogen atom at position 3 and the C-NH2 group at position 2 of the nucleobase, providing a novel hydrogen bond donor/acceptor pattern.

Alternate Name(s):

Pseudo-dG

PRA 10104

2'-Deoxypseudoisoguanosine

C10H13N5O4 

912814-75-6 

Description

The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities.  We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Pseudoiso-dG (PRA 10104) is a guanosine isomer that was recently reported by Hosmane and co-workers.1  We also offer Pseudoiso-dG CEP (BA 0314) , which may be used to incorporate Pseudoiso-dG nucleotides into DNA.

Pseudoiso-dG and Pseudoiso-dG CEP are part of a family that includes Guanosine (PR 3703), 2'-Deoxyguanosine (PR 3452), the isomeric nucleosides Isoguanosine (Iso-G, PR 3735), 2'-Deoxyisoguanosine (Iso-dG, PR 3465), 2'-Deoxypseudoguanosine (Pseudo-dG, PRA 10103), and the phosphoramidite Pseudo-dG CEP (BA 0312).

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367.  See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51, 694-698 and Berry, D. A.; Wotring, L. L.; Drach, J. C.; Townsend, L. B. Nucleosides Nucleotides 1994, 13, 2001-2011.

Notes

2'-Deoxypseudoisoguanosine (Pseudoiso-dG) is related to Iso-dG by transposition of the nitrogen atom at position 3 and the C-NH2 group at position 2 of the nucleobase, providing a novel hydrogen bond donor/acceptor pattern. It is also related to 2'-Deoxypseudoguanosine (Pseudo-dG) by transposition of the C-NH2 group at position 3 and the carbonyl group at position 6.

Alternate Name(s):

Pseudoiso-dG

PRA 10110

N2-(Dimethylaminomethylidene)-
7-deaza-2'-deoxyguanosine

C14H19N5O4 

111902-68-2 

PRA 10120

9-Deaza-2'-deoxyguanosine

C11H14N4O4 

224946-77-4 

Alternate Name(s):

2-Amino-7-(β-D-2-deoxyribofuranosyl)pyrrolo[3,2-d]pyrimidin-4-one

PRA 10130

9-Deazaguanosine

C11H14N4O5 

102731-45-3 

Alternate Name(s):

2-Amino-7-(β-D-ribofuranosyl)[3,2-d]pyrimidin-4-one

PRA 10140

Sangivamycin

C12H15N5O5 

18417-89-5 

Alternate Name(s):

4-Amino-7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine-5-carboxamide

PRA 10150

Toyocamycin

C12H13N5O4 

606-58-6 

Description

Further discounts available for larger orders. Pricing shown is for toyocamycin obtained from fermentation. We also offer synthetic toyocamycin, $325.00 (25 mg); $995.00 (100 mg). Soluble in acetic acid and acidic solution. Moderately soluble in water, methanol, and ethanol.

Alternate Name(s):

4-Amino-5-cyano-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Vengicide

PRA 10160

Triciribine

C13H16N6O4 

35943-35-2 

Description

Triciribine (a.k.a. TCN, Tricyclic Nucleoside, NSC-154020) inhibits Akt (protein kinase B) in a very selective fashion, resulting in apoptosis in human cancer cells (Yang L, Dan HC, Sun M Liu Q, Sun X-m, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ, Cancer Research 2004, 64, 4394-4399). It also inhibits DNA synthesis (Wotring LL, Townsend LB, et. al, Cancer Res. 1990, 50, 4891-9), and as its monophosphate, is active against HIV type 1 (Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res. Hum. Retroviruses 1998, 14, 1315-22).

Notes

Triciribine is a tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.

Alternate Name(s):

Tricyclic Nucleoside, TCN

(6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine)

PRA 10162

Tricyclic Nucleoside Phosphate

C13H17N6O7P 

61966-08-3 

Description

May be useful in treating cancers with tumors that overexpress Akt, shows antiviral, antineoplastic activity, inhibits enzymes in de novo purine nucleotide synthesis.1,2

(1) Porcari, A. R.; Ptak, R. G.; Borysko, K. Z.; Breitenbach, J. M.; Drach, J. C.; Townsend, L. B. Nucleosides, Nucleotides & Nucl. Acids 2003, 22(12), 2171-2193.
(2) Moore, E. C.; Hurlbert, R. B.; Boss, G. R.; Massia, S. P. Biochem. Pharmcol. 1989, 38(22), 4045-4051.

Notes

Inhibits Akt phosphorylation.

Alternate Name(s):

TCN-P, Triciribine Phosphate

6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine 5'-monophosphate

PRA 10170

8-Aza-7-deaza-2'-deoxyguanosine

C10H13N5O4 

100644-70-0 

Alternate Name(s):

PPG

PRA 10175

6-Amino-2-(2-deoxy-β-D-
ribofuranosyl)-2,5-dihydro-4H-
pyrazolo-[3,4-d]-pyrimidin-4-
one

C10H13N5O4 

109737-94-2 

Alternate Name(s):

iso-PPG



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