Pyrrolo-dC CEP

Description: Pyrrolo-dC is a fluorescent analog of 2'-deoxycytidine (Berry, et. Al, Tetrahedron Lett. 2004, 45 (11), 2457-2461). This 2'-deoxycytidine analog is highly fluorescent, exhibiting an emission maximum at 473 nm when incorporated into a 19-mer oligodeoxyribonucleotide, where it base-pairs normally with dG. We also offer the phosphoramidite of pyrrolo-dC (BA 0170) as well as the 2'-O-TBS ribo version, pyrrolo-C CEP (BA 0245), and the 2'-O-Methyl riobo version (BA 0356). BA 0245 and BA 0170 are also available from Glen Research, our development partner for these products. Glen Research also offers the triphosphates of pyrrolo-C and -dC. We offer the two nucleosides (PYA 11090 and PYA 11092) as well as the simple fluorescent pyrrolocytosine heterocycle (i.e., pyrrolo-C aglycone (HC 9060). For photophysical studies on these fluorescent pyrrolopyrimidines, see: Thompson, K. C.; Miyake, N. J. Phys. Chem. B, 2005, 109, 6012-6019.