8-Aza-7-deaza-dA CEP

Notes: The 8-aza-7-deazaadenine nucleobase is isosteric with adenine but offers a different pi-electron distribution and thus an altered dipole moment.

Description: Oligonucleotides containing 8-aza-7-deaza-dA residues exhibit higher T_m's due to stronger base stacking interactions.¹

Use: Employ acetonitrile diluent at the concentration recommended by the synthesizer manufacturer. Use standard coupling protocols; extended coupling is not required. Cleavage from the solid support and nucleobase deprotection with concentrated ammonium hydroxide may be carried out using standard protocols.

(1) Seela, F.; Kaiser, K. Helv. Chim. Acta 1988, 71, 1813-1823.

Product Details

Product Pricing

MF: C₄₃H₅₃N₈O₆P

MW: 808.91

CAS NO: None Assigned

Storage Conditions: -20 ^oC, dry

Purity: Research

Alternate Name:

8-Aza-7-deaza-3'-O-[(diisopropylamino)(2-cyanoethoxy)
phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-
[(dimethylamino)methylidene]-2'-deoxyadenosine

Alternate Name:

PPA CEP

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