2'-Deoxypseudoguanosine CEP
Notes: 2'-Deoxypseudoguanosine (Pseudo-dG) is related to dG by
transposition of the nitrogen atom at position 3 and the C-NH2 group at position
2 of the nucleobase, providing a novel hydrogen bond donor/acceptor pattern. Description: The transposition of atoms or groups in the purine
nucleobase of G/dG provides isomers that have altered base-pairing capabilities.
We offer a family of guanosine isomers in nucleoside and phosphoramidite
forms.
Pseudo-dG CEP (BA 0312) may be used to incorporate Pseudo-dG nucleotides into DNA. It is based on the nucleoside 2'-Deoxypseudoguanosine (Pseudo-dG, synthesized by
Hosmane and co-workers1), which is also available (PRA
10103).
Pseudo-dG CEP and Pseudo-dG are part of a family that includes Guanosine (PR 3703), 2'-Deoxyguanosine (PR 3452), the isomeric nucleosides Isoguanosine (Iso-G, PR 3735), 2'-Deoxyisoguanosine (Iso-dG, PR 3465), 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104), and the phosphoramidite Pseudoiso-dG CEP (BA 0314).
Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers.
1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367. See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51,
694-698. |
