2'-Deoxypseudoisoguanosine (Pseudoiso-dG) is related to Iso-dG by transposition of the nitrogen atom at position 3 and the carbonyl group at position 2 of the nucleobase. It is also related to 2'-Deoxypseudoguanosine (Pseudo-dG) by transposition of the C-NH2 group at position 3 and the carbonyl group at position 6. Pseudoiso-dG CEP may be useful for incorporation into nucleic acids, where it may provide a novel alternate base-pairing scheme.
The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities. We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.
Pseudoiso-dG CEP (BA 0314) may be used to incorporate
Pseudoiso-dG nucleotides into DNA. It is based on the nucleoside 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, originally synthesized by Hosmane and co-workers1), which is also available (PRA
Pseudoiso-dG CEP and Pseudoiso-dG are part of a family
that includes Guanosine
(PR 3703), 2'-Deoxyguanosine
(PR 3452), the isomeric nucleosides Isoguanosine
(Iso-G, PR 3735), 2'-Deoxyisoguanosine
(Iso-dG, PR 3465), 2'-Deoxypseudoguanosine
(Pseudo-dG, PRA 10103), and the phosphoramidite Pseudo-dG
CEP (BA 0312) .
Learn more about these novel compounds and their use by
downloading a Product
Information sheet for our family of guanosine isomers .
1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367. See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51, 694-698 and Berry, D. A.; Wotring, L. L.; Drach, J. C.; Townsend, L. B. Nucleosides Nucleotides 1994, 13, 2001-2011.