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BA 0343
Product Information Molecular Structure

dNaM CEP

Notes: Half of a novel base pair that achieves pair recognition through hydrophobic interactions.

Description: The dNaM (BA 0343) and d5SICS (BA 0344) matched pair appears to be a very interesting novel base pair, achieving pair recognition through hydrophobic interactions that rivals the A-T and G-C pairing in the natural genetic alphabet.1-7 In addition, they have been shown to be well-replicated by DNA polymerases under steady-state conditions, regardless of sequence. The fidelity and efficiency of dNaM and d5SICS replication approach those of natural synthesis. Both dNaM and d5SICS are also efficiently transcribed by T7 RNA polymerase in either direction. In 2009, the Romesberg and Marx groups reported data that showed KlenTaq polymerase induces the dNaM-d5SICS unnatural base pair to adopt a natural Watson-Crick like strucutre.8 More recently, an additional coupling partner for dNaM has been identified which gives higher amplification efficiency and fidelity under standard PCR conditions.9 For more information, download a Product Information Sheet for BA 0343 here.

1. Seo, Y.J.; Matsuda, S.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131, 5046-7.

2. Seo, Y.J.; Hwang, G.T.; Ordoukhanian, P.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131, 3246-52.

3. Seo, Y.J.; Romesberg, F.E. ChemBioChem, 2009, 10, 2394-2400.

4. Hwang, G.T.; Hari, Y.; Romesberg, F.E. Nucleic Acids Res., 2009, 37, 4757-63.

5. Hari, Y.; Hwang, G.T.; Leconte, A.M.; Joubert, N.; Hocek, M.; Romesberg, F.E. ChemBioChem, 2008, 9, 2796-9.

6. Hwang, G.T.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130, 14872-82.

7. a)Leconte, A.M.; Hwang, G.T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F.E J. Am. Chem. Soc., 2008, 130, 2336-43. b) Lavergne, T.; Lamichhane, R.; Malyshev, D. A.; Li, Z.; Li, L.; Sperling, E.; Williamson, J.R.; Miller, D.P.; Romesberg, F.E. ACS Chem Biol. 2016, 11 1347-1353. c) Betz, K.; Malyshev, D.A.; Lavergne, T.; Welte, W.; Diederichs, K.; Romesberg, F.E.; Marx, A. J. Am. Chem. Soc. 2013 135 18637-18643.

8. Betz, K.; Malyshev, D.A.; Lavergne, T.; Welte, W.; Diederichs, K.; Dwyer, T.J.; Ordoukhanian, P.; Romesberg, F.E.; Marx, A. Nat. Chem. Biol. 2012, 8, 612-614.

9. Li, L.; Degardin, M.; Lavergne, T.; Malyshev, D.A.; Dhami, K.; Ordoukhanian, P.; Romsberg, F.E. J. Am. Chem. Soc. 2014, 136, 826-829.

dNaM CEP
Product Details Product Pricing

MF: C46H53N2O7P

MW: 776.98

CAS NO: 1117893-10-3

Storage Conditions: Dry, -20 C

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

3-(3-O-[(Diisopropylamino)(2-cyanoethoxy)phosphino]-
5'-O-(4,4'-dimethoxytrityl)-2'-deoxyribofuranosyl)-2-
methoxy naphthalene
Unit Weight Unit Price Quantity
100 µmol $415.00
0.25 g $995.00
 
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