5'-Click-easyTM MFCO CEP
Notes: BA 0368 from our Click-matesTM collection is for the installation of a monofluoro-substituted cyclooctyne (MFCO) into an oligonucleotide for subsequent copper-free click elaboration. Description: The click cycloaddition reaction is a remarkably efficient and reliable process for bioconjugation even in the presence of the diverse array of functional groups found in DNA and the variety of scientifically intriguing ligation partners. Pigge and co-workers have reported a monofluoro substituted cyclooctyne (MFCO) motif that efficiently undergoes click ligation without catalysis.1,2 Based on this work, we now offer 5’-Click-easyTM MFCO CEP (BA 0368) for introduction of the MAFCO moiety into oligonucleotides.
For more information, download a Product
Information Sheet for BA 0368 here.
For a complete listing of our reagents for click chemistry,
please see our Click-matesTM Collection page.
References
1) Schultz, M.K.; Parameswarappa, S.G.; Pigge, F. C. Organic Lett. 2010, 12, 2398-2401. 2) Martin, M.E.; Parameswarappa, S.M.; O'Dorisio, M.S.; Pigge, F.C.; Schultz, M.K. Bioorg. & Med. Chem. Lett. 2010, 20, 4805-4807.
Note: BA 0368 is protected by US 7,807,619, the rights of which are assigned to The Regents of the University of California. Additional patents covering methods for their use in the modification of biomolecules are pending. It may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and are not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.
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