5'-Click-easyTM BCN CEP I
Notes: BA 0372 is for the installation of a strained cyclooctyne (BCN) into an oligonucleotide for subsequent copper-free click elaboration. Description:
The click cycloaddition reaction is a remarkably efficient and reliable process for bioconjugation even in the presence of the diverse array of functional groups found in DNA and the variety of scientifically intriguing ligation partners. Our 5’-Click-easyTM BCN CEP (BA 0372)1 can be used to prepare oligonucleotides for subsequent clean and efficient copper-free click cycloaddition. In our hands, the bicyclo[6.1.0]nonyne (BCN)2 is a superior scaffold for the strain-promoted alkyne-azide cycloaddition.3
For more information, download a Product
Information Sheet for BA 0372 here.
Please see our Click-matesTM Collection for a selection of click-able azides for use with this remarkable click alkyne.
References
1) Patent pending. 2) Dommerholt, J.; Schmidt, S.; Temming, R.; Hendricks, L.J.A.; Rutjes, F.P.J.T.; van Hest, J.C.M.; Lefeber, D.J.; Friedl, P.; van Delft. F.L. . Angew. Chem. Int. Ed. 2010, 49, 9422-9425. 3) Debets, M.F.; van Berkel, S.S.; Dommerholt, J.; Dirks, A.J.; Rutjes, F.P.J.T.; van Delft, F.L. Accounts of Chem. Res. 2011, 44, 805-815.
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