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BA 0372
Product Information Molecular Structure

5'-Click-easy® BCN CEP I

Notes: BA 0372 is for the installation of a strained cyclooctyne (BCN) into an oligonucleotide for subsequent copper-free click elaboration.

Description: 

The click cycloaddition reaction is a remarkably efficient and reliable process for bioconjugation even in the presence of the diverse array of functional groups found in DNA and the variety of scientifically intriguing ligation partners. Our 5-Click-easyTM BCN CEP (BA 0372)1 can be used to prepare oligonucleotides for subsequent clean and efficient copper-free click cycloaddition. In our hands, the bicyclo[6.1.0]nonyne (BCN)2 is a superior scaffold for the strain-promoted alkyne-azide cycloaddition.3

For more information, download a Product Information Sheet for BA 0372 here.

Please see our Click-matesTM Collection for a selection of click-able azides for use with this remarkable click alkyne.

References

1) Patent pending.

2) Dommerholt, J.; Schmidt, S.; Temming, R.; Hendricks, L.J.A.; Rutjes, F.P.J.T.; van Hest, J.C.M.; Lefeber, D.J.; Friedl, P.; van Delft. F.L. . Angew. Chem. Int. Ed. 2010, 49, 9422-9425.

3) Debets, M.F.; van Berkel, S.S.; Dommerholt, J.; Dirks, A.J.; Rutjes, F.P.J.T.; van Delft, F.L. Accounts of Chem. Res. 2011, 44, 805-815.

5'-Click-easy<sup>®</sup> BCN CEP I
Product Details Product Pricing

MF: C20H33N2O2P

MW: 364.46

CAS NO: 1393524-83-8

Storage Conditions: Dry, -20 C

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

2-((-1R,8S,9r)-bicyclo[6.1.0]non-4-yn-9yl)ethyl(2-
cyanoethyl)diisopropyl phosphoramidite
Unit Weight Unit Price Quantity
100 µmol $370.00
250 µmol $875.00
 
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