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BL 2030
Product Information Molecular Structure

3'-BBQ-650® CPG III

Notes: BlackBerry® Quencher 650 CPG III (3'-BBQ-650® CPG III) is used to install BBQ-650® at the 3' end of an oligonucleotide, and is more efficiently cleaved from the solid support than its predecessor BL 2020.

Description: Our BlackBerry® quenchers are excellent quenchers of long-wavelength fluorophores in both FRET and contact modes. They exhibit an absorption maximum at ca. 650 nm and have useful absorbance between 550 and 750 nm. The tricyclic 8-alkoxyjulolidine moiety is a powerful pi-donor that affords a surprising bathochromic shift when compared to related compounds. A key advantage of the BBQ-650® is its stability to ammonia and oxidation conditions. 3-BBQ-650® CPG III (BL 2030) utilizes a 1,3,5-triol framework, which is two methylene units longer than the 1,2,3-triol framework that is employed with 3-BBQ-650® CPG (BL 2010) and 3-BBQ-650®CPG II (BL 2020). The one-carbon extension between each of the oxygen atoms provides an architecture that allows a one step cleavage with AMA while also minimizing the occurrence of impurities that lack the quencher tag. The oligo purity observed with BL 2030 after cleavage and deprotection rivals that seen with BL 2020 after the two step protocol. Like BL 2020, BL 2030 also has a fast cleaving linker, but AMA appears to provide markedly superior oligo yield as compared to NH4OH. Our 3'-BBQ-650® CPG , BL 2010 containing a succinate linker also allows for incorporation at the 3'-terminus. In addition, we offer versions for incorporation into oligonucleotides internally (BBQ-650®-dT CEP, BL 1010), or at the 5'-terminus (5'-BBQ-650® CEP, BL 1020 and 5'-BBQ-®(DMT) CEP, BL 1030). BBQ-650®NHS Ester (BL 3010) is also available for postsynthetic labeling of amine-modified oligonucleotides.

Download a product information sheet for BL 2030 here. Download a brief overview of BlackBerry® Quenchers here.

3'-BBQ-650<sup>®</sup> CPG III
Product Details Product Pricing



CAS NO: None Assigned

Storage Conditions: -20 oC, dry, dark


Stock maintained. Ships within 1-3 days.

Alternate Name: 

BlackBerry® Quencher 650 CPG III
Unit Weight Unit Price Quantity
200nmol columns (pkg of 4) $112.99
100mg $166.80
1µmol columns (pkg of 4) $260.48
1g $1,288.16
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