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PR 3735
Product Information Molecular Structure

Isoguanosine

Notes: 

Isoguanosine (Iso-G, PR 3735) and 2'-Deoxyisoguanosine (Iso-dG, PR 3465) are isomeric with G/dG, differing by transposition of the carbonyl group at position 6 of G or dG with the C-NH2 group at position 2, providing a novel hydrogen bond donor/acceptor pattern.

Description: The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities. We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Isoguanosines are important in the field of non-natural base pairing. In 1989, Benner and co-workers1 reported the enzymatic incorporation of iso-G into RNA and DNA and characterized the distinct non-natural base pairing that resulted, especially pairing involving the similarly transposed isomer of dC known as iso-dC (we offer the closely-related compound 5-Methyliso-dC, PY 7255

Iso-G and Iso-dG are part of a family that includes Guanosine (PR 3703) , 2'-Deoxyguanosine (PR 3452) , the isomeric nucleosides 2'-Deoxypseudoguanosine (Pseudo-dG, PRA 10103) , 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104) and the phosphoramidites Pseudo-dG CEP (BA 0312) and Pseudoiso-dG CEP (BA 0314)

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Switzer, C. Y.; Moroney, S. E.; Benner, S. A. J. Am. Chem. Soc. 1989, 111, 8322-8323.

Isoguanosine
Product Details Product Pricing

MF: C10H13N5O5

MW: 283.21

CAS NO: 1818-71-9

Storage Conditions: 5 oC

Purity≥97%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

Iso-G;

2-hydroxy adenosine;

1,2-dihydro-2-oxo
adenosine
Unit Weight Unit Price Quantity
10 mg $105.00
50 mg $286.00
 
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