Isoguanosine
Notes: Isoguanosine (Iso-G, PR 3735) and 2'-Deoxyisoguanosine (Iso-dG,
PR 3465) are isomeric with
G/dG, differing by transposition of the carbonyl group at position 6 of G or dG
with the C-NH2 group at position 2, providing
a novel hydrogen bond donor/acceptor pattern. Description: The
transposition of atoms or groups in the purine nucleobase of G/dG provides
isomers that have altered base-pairing capabilities. We offer a family of guanosine isomers
in nucleoside and phosphoramidite forms.
Isoguanosines
are important in the field of non-natural base pairing. In 1989, Benner and
co-workers1 reported the enzymatic incorporation of iso-G into RNA
and DNA and characterized the distinct non-natural base pairing that resulted,
especially pairing involving the similarly transposed isomer of dC known as
iso-dC (we offer the closely-related compound 5-Methyliso-dC,
PY 7255
Iso-G
and Iso-dG are part of a family that includes Guanosine
(PR 3703) , 2'-Deoxyguanosine
(PR 3452) , the isomeric nucleosides
2'-Deoxypseudoguanosine
(Pseudo-dG, PRA 10103) ,
2'-Deoxypseudoisoguanosine
(Pseudoiso-dG, PRA 10104)
and the phosphoramidites Pseudo-dG
CEP (BA 0312)
and Pseudoiso-dG
CEP (BA 0314)
Learn
more about these novel compounds and their use by downloading a Product
Information sheet for our family of guanosine isomers
.
1. Switzer,
C. Y.; Moroney, S. E.; Benner, S. A. J.
Am. Chem. Soc. 1989, 111,
8322-8323. | 
