View Shopping Cart   Checkout   Order Catalog  

PRA 10160
Product Information Molecular Structure

Triciribine

Notes:  Triciribine is a tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.

Description: Triciribine (a.k.a. TCN, Tricyclic Nucleoside, NSC-154020) inhibits Akt (protein kinase B) in a very selective fashion, resulting in apoptosis in human cancer cells (Yang L, Dan HC, Sun M Liu Q, Sun X-m, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ, Cancer Research 2004, 64, 4394-4399). It also inhibits DNA synthesis (Wotring LL, Townsend LB, et. al, Cancer Res. 1990, 50, 4891-9), and as its monophosphate, is active against HIV type 1 (Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res. Hum. Retroviruses 1998, 14, 1315-22).

Triciribine
Product Details Product Pricing

MF: C13H16N6O4

MW: 320.31

CAS NO: 35943-35-2

Storage Conditions: 5 oC

Purity≥97%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

Tricyclic Nucleoside, TCN

Alternate Name: 

(6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-
pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine)
Unit Weight Unit Price Quantity
10 mg $237.50
 
View Shopping CartCheckout