Tricyclic Nucleoside Phosphate
Notes: Inhibits Akt phosphorylation. Description: May be useful in treating cancers with tumors that overexpress Akt, shows antiviral, antineoplastic activity, inhibits enzymes in de novo purine nucleotide synthesis.1,2
(1) Porcari, A. R.; Ptak, R. G.; Borysko, K. Z.; Breitenbach, J. M.; Drach, J. C.; Townsend, L. B. Nucleosides, Nucleotides & Nucl. Acids 2003, 22(12), 2171-2193.
(2) Moore, E. C.; Hurlbert, R. B.; Boss, G. R.; Massia, S. P. Biochem. Pharmcol. 1989, 38(22), 4045-4051.
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