Pyrrolo-dC
Notes: Fluorescent analog of 2’-deoxycytidine. Description: Pyrrolo-dC is a fluorescent analog of 2'-deoxycytidine (Berry, et. Al, Tetrahedron Lett. 2004, 45 (11), 2457-2461). It is highly fluorescent, exhibiting an emission maximum at 473 nm when incorporated into a 19-mer oligodeoxyribonucleotide, where it base-pairs normally with dG. We also offer pyrrolo-C, a fluorescent analog of cytidine. The phosphoramidites of pyrrolo-C and pyrrolo-dC suitable for oligonucleotide synthesis are available from Berry & Associates (Products BA 0170 and BA 0245) or from Glen Research, our development partner for these products. Glen Research also offers the triphosphates of pyrrolo-C and -dC. We also offer the simple fluorescent pyrrolocytosine heterocycle (i.e., pyrrolo-C aglycone (HC 9060). For photophysical studies on these fluorescent pyrrolopyrimidines, see: Thompson, K. C.; Miyake, N., J. Phys. Chem. B, 2005, 109, 6012-6019.
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