6-Methyl-3-(β-D-2-ribofuranosyl)pyrrolo[2,3-d]
pyrimidin-2-one

Description: Pyrrolo-C is a fluorescent analog of cytidine (Berry, et. Al, Tetrahedron Lett. 2004, 45 (11), 2457-2461). It is highly fluorescent, exhibiting an emission maximum at approximately 473 nm. We also offer pyrrolo-dC, a fluorescent analog of cytidine. The phosphoramidites of pyrrolo-C and pyrrolo-dC suitable for oligonucleotide synthesis are available from Berry & Associates (Products BA 0170 and BA 0245) or from Glen Research, our development partner for these products. Glen Research also offers the triphosphates of pyrrolo-C and -dC. We also offer the simple fluorescent pyrrolocytosine heterocycle (i.e., pyrrolo-C aglycone (HC 9060). For photophysical studies on these fluorescent pyrrolopyrimidines, see: Thompson, K. C.; Miyake, N., J. Phys. Chem. B, 2005, 109, 6012-6019.