3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]
pyrimidine-2,7(8H)-dione

Description:  Download a brief overview here. Known as "dF" or "P". Ribo version fluoresces at 385 nm (Bergstrom, D. E.; Inoue, H.; Reddy, P. A., J. Org. Chem., 1982, 47, 2174-2178; Bergstrom, D., et. Al, Synlett, 1992, 179-188). Has been incorporated into oligonucleotides, where dF pairs with dG, resulting in a higher melting temperature (Inoue, H.; Imura, A.; Ohtsuka, E., Nucleic Acids Res., 1985, 13, 7119-7128). In triple helices, dF pairs well with dA (Staubli, A. B.; Dervan, P. B., Nucleic Acids Res. 1994, 22, 2637-2642). We also offer the phosphoramidite version (Product # BA 0238, CAS Reg. No. 162585-09-3), which has been used for oligonucleotide synthesis (Durland, R. H.; Rao, T. S.; Jayaraman, K.; Revankar, G. R., Bioconjugate Chem., 1995, 6, 278-282), where it is known as "P", and serves as a fluorescent replacement of T in targeting AT base pairs during triplex formation.